Dr. Kanneganti’s lab focuses on understanding how the innate immune system recognizes and responds to infection and how genetic mutations in innate immunity affect the development of inflammatory and autoimmune diseases in humans. Her studies have unraveled key roles for several of the Nod-like Receptors (NLRs) and inflammasomes in response to pathogens and endogenous danger signals (Nature 440(7081):233-36; Nature Immunology 7(6):576-82, 2011; Cancer Cell 20(5):649-60, 2011; Nature 488(7411):389-93, 2012; Nature Immunology 14(5):480-488, 2013); Nature Immunology 2015). Amongst her other major contributions are the discovery of the role of IL-1α signaling pathway in sterile inflammation (Nature 498(7453):224-7); the discovery of diet-induced changes in the microbiota composition which can lead to the development of osteomyelitis (Nature 516(7530):246-9); and that caspase-1 and caspase-8 act redundantly in maturing IL-1β during osteomyelitis (Nature 516(7530):246-9). In addition, her lab recently identified a novel ‘non-canonical’ pathway for AIM2 inflammasome activation engaged by Francisella infection that critically relies on the interferon-regulatory factor IRF1 (Nature Immunology 2015 Mar 16. doi: 10.1038/ni.3118). These are just some examples of her research that has significantly propelled the field of immunology forward while contributing to broader research areas, including infectious diseases, cancer, and autoimmunity. She received AAI-BD Biosciences Investigator Award from the American Association of Immunologists (AAI) for her contributions to the field of Immunology.
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