CRISPR/Cas9 library screening uncovered methylated PKP2 as a critical driver of lung cancer radioresistance by stabilizing β-catenin
Radiation resistance is a serious explanation for lung most cancers therapy failure. Armadillo (ARM) superfamily proteins take part in numerous basic mobile processes; nevertheless, whether or not ARM proteins regulate radiation resistance just isn’t totally understood. Right here, we used an unbiased CRISPR/Cas9 library display screen and recognized plakophilin 2 (PKP2), a member of the … Read more