Rheb1 protects against cisplatin-induced tubular cell death and acute kidney injury via maintaining mitochondrial homeostasis.

Rheb1 protects against cisplatin-induced tubular cell death and acute kidney injury via maintaining mitochondrial homeostasis.

Ras homolog enriched in brain (Rheb1), a small GTPase, plays an important role in regulating cell growth, differentiation, and survival. However, the role and mechanism Rheb1 in tubular cell survival and acute kidney injury (AKI) is still unexplored. Here we find that Rheb1 signal is activated in the kidney tubules AKI patients and cisplatin-treated mice. … Read more Rheb1 protects against cisplatin-induced tubular cell death and acute kidney injury via maintaining mitochondrial homeostasis.