Ras homolog enriched in brain (Rheb1), a small GTPase, plays an important role in regulating cell growth, differentiation, and survival. However, the role and mechanism Rheb1 in tubular cell survival and acute kidney injury (AKI) is still unexplored. Here we find that Rheb1 signal is activated in the kidney tubules AKI patients and cisplatin-treated mice. … Read more Rheb1 protects against cisplatin-induced tubular cell death and acute kidney injury via maintaining mitochondrial homeostasis.
TDP-43 pathology is characteristic that characterizes the disease amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP). TDP-43 experience some posttranslational modifications that can alter the biological activity and tendency to aggregate, which is a common characteristic of the different neurodegenerative conditions. new evidence provided by the present study refers to the TDP-43 acetylation in … Read more HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo.
natural killer (NK) cells of the innate lymphocytes that play an important role in preventing the development of cancer by monitoring immune system to eradicate the abnormal cells. Since the ex vivo expanded NK cell cytotoxic activity against a variety of cancers, including breast cancer, their clinical potential as an immune-oncogenic therapy has been studied … Read more XRP44X Enhances the Cytotoxic Activity of Natural Killer Cells by Activating the c-JUN N-Terminal Kinase Signaling Pathway.