HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo.

TDP-43 pathology is characteristic that characterizes the disease amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP). TDP-43 experience some posttranslational modifications that can alter the biological activity and tendency to aggregate, which is a common characteristic of the different neurodegenerative conditions. new evidence provided by the present study refers to the TDP-43 acetylation in … Read more